Nerve fibers and nerve endings
Nerve fibers
- These are neuronal processes (axis cylinders), surrounded by a coat of chain-forming glial cells (in the peripheral nervous system) or of their processes (in the central nervous system)
- Depending on the glial coat architecture, one may classify the fibers into unmyelinated and myelinated nerve fibers
- Glial cells of the peripheral nervous system that participate in the nerve fiber formation are called Schwann cells
Nerve fibers of the peripheral nervous system
Unmyelinated nerve fibers
- are cords covered by a basement membrane. Their thickness is 1-4 μm. They contain several (5-20) thin neuronal processes (mainly dendrites), which are immersed partially or entirely into pits on Schwann cell surfaces
- provide for low (1-2 m/sec) speed of excitation conduction
Myelinated nerve fibers
- are also cords covered by a basement membrane, though the thickness is 8-20 μm. They contain one neuronal process (usually axon), which is immersed into Schwann cell cytoplasm along the entire nerve length. The fiber is surrounded by a helix of myelin layers folded in numerous coils. These are folds of double-layered plasma membrane in Schwann cells (mesaxon)
- Some cell portions (at the boundaries between adjacent Schwann cells) have no myelin coat and called nodes of Ranvier
- A depolarization wave propagates in a saltatory way from one node of Ranvier to another. This ensures a high (5-120 m/sec) speed of nerve impulse conduction
Nerve fibers of the central nervous system
Myelinated nerve fibers
- All the surface of neuronal processes is surrounded by concentric spiral stratified coats, which are formed by thin flattened processes of glial cells (oligodendroglia of the central nervous system)
- A glial cell body gives rise to 40-50 cell processes that take part in the coat formation for several fibers at the same time
Unmyelinated neuronal processes
- have no specialized glial coats
- are free to "float" among neurons and glia; the processes are separated from one another by astrocyte processes
Nerve endings
- are terminal parts of sensory dendrites and motor axons
- depending on their functions, they may be classified into receptive (afferent) and effector (efferent) endings
Receptive (afferent) nerve endings are terminal dendritic branches of sensory neurons:
- free endings (no glial envelope around the process)
- unencapsulated endings (the processes are covered by glial elements)
- encapsulated endings (the processes are covered by a glial coat and both of them are ensheathed by a connective tissue capsule)
Effector (efferent) nerve endings
- are terminal parts of motor axons
- form chemical synapses where the postsynaptic region is represented by specialized plasma membrane portions of functioning organ tissue elements (muscles, glandular cells)
- neurovascular synapses provide for neurohormonal traffic from terminals of efferent neurosecretory cell processes into the capillary blood stream