It is a rather frequent event when incomplete mitosis that has been blocked immediately after nuclear segregation results in formation of bi- or multinucleated cells (the latter case is not so frequent). Some organs, e.g. the liver and the heart, have a considerable proportion of bi- and multinucleated cells reaching 15-25% of the entire population. The image depicts a multinucleated giant cell of a foreign body. These cells are formed in the connective tissue around foreign bodies that are difficult to destroy (silicon particles, glass, surgical suture). In some infectious diseases, giant cells of granulomas contain up to 200 nuclei. The image also depicts a small rounded electron-dense cell in the state of apoptosis. There is a big nucleus with partially condensed disintegrated chromatin; it is surrounded by the dense cytoplasm containing some remnants of organelles as well as inclusions. The cell has a virtually intact plasma membrane. The cell is entirely immersed into the cytoplasm of a macrophage. The cell death has caused no physical damage in the tissue as the cell is completely devoured by the phagocyte.