Назад Mitotic anaphase in a dividing lymphocyte; cell apoptosis-
Mitotic anaphase in a dividing lymphocyte of a lymphatic node; apoptosis. TEM image. 3600X.

Anaphase is defined principally by separation and migration of sister chromatids #1, #2 to the opposite poles of the cell. The image depicts one of dividing lymphocytes. There are some other cells like small and medium-sized lymphocytes #1, #2 and large lymphocytes or lymphoblasts in interphase.

The mechanism of chromosome segregation is rather complicated; it involves all three types of microtubules in the mitotic spindle. In anaphase, motor proteins called kinesins bind the neighboring parallel polar microtubules together. The anaphase is very rapid compared to other mitotic phases; it does not exceed one minute usually. So it may be seldom captured by an electron microscope study. Here you see an actual end of anaphase transforming into the next stage of cell division or telophase. It is indicated, for example, by a started formation of future nuclear envelopes #1, #2, #3 around certain chromosomes.

For whatever reason, some of newly formed cells do not meet the vital requirements and thereby have to be eliminated. This is generally provided by a genetically programmed cell death, apoptosis. If the apoptotic mechanism is activated in a cell, it usually dies with no destruction or disintegrates into large fragments. Three lymphocytes that are being disintegrated like this are distinguished in the cytoplasm of a macrophage in the right bottom segment of the image. Pprogrammed cell death is a physiological process; together with mitosis, these are normal instruments of morphogenesis.